汪文倩（博士）

学位：工学博士

职称/职务：讲师

E-mail：17853509330@163.com

研究方向：天然产物开发与神经保护功能评价

汪文倩，女，博士，讲师，主要研究方向为天然产物开发与神经保护功能评价。研究内容主要包括石莼多糖的绿色提取与、可控降与活性筛选、肠道菌群与代谢组学分析、鞘脂代谢通路调控机制解析，以及多糖与益生菌协同干预帕金森病的增效机制研究等。2026年6月获天津科技大学轻工技术与工程专业工学博士学位。以第一作者在《International Journal of Biological Macromolecules》、《Journal of Agricultural and Food Chemistry》、《Foods》等杂志发表SCI论文。

主持或参与科研项目（课题）情况：

1.天津科技大学优秀博士论文创新项目，石莼多糖和低聚糖的制备及其调节帕金森病的作用机制研究，主持，2024-2026

2.天津市科技计划项目，抗阿尔茨海默病的多功能抑制剂设计和作用机制研究，参与，2023-2026

3.天津市研究生科研创新项目，松茸多糖对神经退行性疾病帕金森病的干预及机制研究，参与，2022-2024

4.国家自然科学基金面上项目，Aβ聚集诱导发光体系构建及其在细胞内Aβ聚集抑制剂筛选中的应用，参与，2019-2022

5.国家重点研发计划，工业多酶催化体系构建与机制研究，参与，2019-2021

6.天津市应用基础及前沿技术研究计划重点项目，聚集诱导荧光探针-α-突触核蛋白融合体系构建及其在聚集抑制剂筛选中的应用，参与，2018-2021

近年来发表的代表性论文：

1.Wenqian Wang, Lili Qu, Zhan Cui, Fuping Lu, Li Li, and Fufeng Liu. Citrus flavonoid hesperetin inhibits α-synuclein fibrillogenesis, disrupts mature fibrils and reduces their cytotoxicity: in vitro and in vivo studies. Journal of Agricultural and FoodChemistry, 2023, 71: 16174−16183.

2.Wenqian Wang, Xinni Wu, Kuo Meng, Xingmiao Lu, Fuping Lu, Fufeng Liu. Orally administered Bacillus licheniformis F0726 attenuates MPTP/P-induced neurodegeneration by modulating gut microbiota and suppressing inflammatory responses. Journal ofAgricultural and Food Chemistry, 2025, 73: 32013−32025.

3.Wenqian Wang, Xinyu Wang, Wen Gao, Zhan Cui, Huitu Zhang, Fuping Lu, Fufeng Liu. Ulvan inhibits α-synuclein fibrillation and disrupts the mature fibrils: In vitro and in vivo studies. International Journal of Biological Macromolecules, 2022, 211: 580-591.

4.Wenqian Wang, Xinming Wu, Qingfu Zhang, Tong Zhang, Luying Jiang, Lili Qu, Fuping Lu, Fufeng Liu. Tetrahydrofolic acid accelerates amyloid fibrillization, decreases cytotoxic oligomers and suppresses their toxicity. International Journal of Biological Macromolecules, 2025, 290: 139041.

5.Wenqian Wang, Qingfu Zhang, Tong Zhang, Fuping Lu, Fufeng Liu. Ulva polysaccharide alleviates Parkinson's disease by regulating inflammation, oxidative damage, and gut microbiota. International Journal of Biological Macromolecules, 2026, 339: 149946.

6.Wenqian Wang, Jinbi Li, Fuping Lu and Fufeng Li. Ultrasound-Assisted Multi-Enzyme Extraction for Highly Efficient Extraction of Polysaccharides from Ulva Lactuca. Foods, 2024, 13: 891.

7.Fenghua Wang, Ying Wang, Luying Jiang,Wenqian Wang, Jingcheng Sang, Xinyu Wang, Fuping Lu, Fufeng Liu. The foodadditive fast green FCF inhibits α‑synuclein aggregation, disassembles mature fibrils and protects against amyloid-inducedneurotoxicity. Food & Function. 2021, 12: 5465.

专利

1.彭勃，刘夫锋，王雪萍，汪文倩，李锦涛，李林，柏桦。多尺寸α-突触核蛋白聚集体的快速制备方法。中国专利CN202411469488.2

2.刘夫锋，柴成程，汪文倩，张佳钰，路福平。一种石莼多糖裂解酶突变体及其应用。中国专利：CN202110002931.5。