学位：博士研究生

职称/职务：高级实验师

E-mail：wuyao.7788@163.com

研究方向：蛋白质棕榈酰化功能

吴瑶瑶，女，博士，高级实验师。2017年3月获得中国科学技术大学细胞生物学专业理学博士学位。2017年5月至2021年5月，在新乡医学院精神神经医学研究院从事蛋白质棕榈酰化与神经退行性疾病的相关性研究和大分子药物的研发工作。2021年5月至今，在枣庄学院食品科学与制药工程学院实验教学中心担任实验师，主要参与有机化学、无机与分析化学实验课教学。

主持或参加科研项目（课题）情况:

1.国家自然科学基金青年项目：PPT1介导RalA棕榈酰化修饰调控树突棘发育的分子机制，负责人，2022-2024.

2.山东省自然科学基金青年项目：RalA棕榈酰化修饰调控肝细胞癌侵袭和迁移的分子机制，负责人，2025-2027.

3.浙江省神经损伤修复新靶点及药物研究重点实验室开放基金项目：Sarm1介导线粒体在微管上的锚定在阿尔茨海默病轴突变性中的作用，参与人，2023-2026

近年来发表的代表性论文（“*”通讯作者）：

1.ShuyanDuan^*;YanqiuYuan;ZhaoyiWei;XiaoyueCai;YaoyaoWu^*(2025).Expression, purification, crystallization, and pan-cancer analysisi of the human RNA3’-terminal phosphate cyclase.Applied Biochemistry and Microbiology

2.Gui-yuan Song; Qing-hua Yu; Xue-kun Xing; Xin-ming Fan; Si-guang Xu; Wen-bo Zhang;Yao-yaoWu; Nan Zhang; Tian-zhu Chao; Fei Wang; Cheng-shi Ding; Cun-yang Guo; Li Ma; Chang-ye Sun;Shu-yan Duan; Ping Xu ; The YTHDC1 reader protein recognizes and regulates the lncRNA MEG3following its METTL3-mediated m6 A methylation: a novel mechanism early during radiation-inducedliver injury., Cell Death and Disease, 2025, 16(1): 127

3.Shuyan Duan;Yaoyao Wu; Tianzhu Chao; Nan Zhan; Zhaoyi Wei; Rui Ji*，Improving the catalytic activity and thermostability of Aspergillus niger xylanase through computational design，Protein expression and purification 223(2024) 106561

4.Nan Zhang; Gui-yuan Song; Qing-hua Yu; Xin-ming Fan; Wen-shuo Zhang; Yong-jian Hu; TianzhuChao;Yao-yao Wu; Shu-yan Duan; Fei Wang; Rui-peng Du; Ping Xu ; Evaluation of the lncRNAmiRNA-mRNA ceRNA network in lungs of miR-147−/− mice, Frontiers in Pharmacology, 2024, 15:1335374

5.Nan Zhang; Guiyuan Song; Yongjian Hu; Xia Wang; Tianzhu Chao;Yaoyao Wu; Ping Xu*，Analysis ofIncRNA-miRNA-mRNA Expression in the Troxerutin-Mediated Prevention of Radiation-Induced Lung Injury in Mice., J Inflamm Res.，2023.

6.Gui-yuan Song; Yong-jian Hu; Nan Zhang; Fei Wang; Tian-zhu Chao;Yao-yao Wu; Yu-feng Li;Ping Xu*，Construction and validation of a competing endogenous RNA network in the thymus of miR-147-/-mice, International Immunopharmacology，2023, 117(109896): 1-12

7.WuYaoyao; ZhangQianqian; QiYawei; Gao Jingjing; Li Wenqiang; Lv Luxiang; ChenGuanjie; Zhang Zhongjian; Yue Xuyi; Peng Shiyong*，Enzymatic activity of palmitoyl-protein thioesterase-1 in serum from schizophrenia significantly associates with schizophrenia diagnosis scales，Journal of Cellular and Molecular Medicine，2019, 23(9): 6512-6518

8.WuYaoyao; Xu Kaibiao; Qi Huayu*，Domain-functional analyses of PIWIL1 and PABPC1indicate their synergistic roles in protein translation via 3'-UTRs of meiotic mRNAs，Biology ofReproduction，2018, 99(4): 773-788

9.Xu, K., Yang, L., Zhao, D.,Wu, Y., Qi, H.^*AKAP3 synthesis is mediated by RNA binding proteins and PKA signalling during mouse spermiogenesis. Biology of Reproduction 90(6): 1-14 (2014).

专利：

1.徐萍,于清华,宋桂圆,张楠,段树燕,吴瑶瑶,晁天柱,郭存洋,王飞。一种microRNA-22-5p靶向调控Bcl-2的方法及其在电离辐射中的应用。2023113974788